alexa Withania Coagulans Fruit Extract Protects Diabetic Nephropathy Through Inhibition Of Inflammatory Cytokines And Oxidative Stress In Streptozotocin-induced Diabetic Rats
ISSN: 2153-0769

Metabolomics:Open Access
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8th International Conference and Exhibition on Metabolomics & Systems Biology
May 08-10, 2017 Singapore

Naheed Amir, Shreesh Ojha, Juma Alkaabi, Azimullah Sheikh and Abdu Adem
United Arab Emirates University, UAE
Posters & Accepted Abstracts: Metabolomics
DOI: 10.4172/2153-0769-C1-038
Abstract
Diabetes nephropathy (DN) is the major determinant of morbidity and mortality in patients with diabetes. The development of DN is associated with increase in levels of inflammatory cytokines and localized tissue oxidative stress. Hyperglycemic control in diabetes is a key to prevent the development and progression of DN. Therefore, the present study was carried out to investigate the changes in oxidative and inflammatory status in streptozotocin-induced diabetic rats’ kidneys and serum following treatment with Withania coagulans, a popular herb of ethnomedicinal significance. The key markers of oxidative stress and inflammation such as inflammatory cytokines (IL-1β, IL-6, and TNF-α) and immunoregulatory cytokines (IL-4 and IFN-γ) were increased in kidneys along with significant hyperglycemia. However, treatment of four-month diabetic rats with Withania coagulans (10 mg/kg) for 3 weeks significantly attenuated hyperglycemia and reduced the levels of pro-inflammatory cytokines in kidneys. In addition, Withania coagulans treatment restored the glutathione levels and inhibited lipid peroxidation along with marked reduction in kidney hypertrophy. This study demonstrates that Withania coagulans improved hyperglycemia and maintained antioxidant status and reduced the pro-inflammatory markers in kidneys, which may subsequently reduce the development and progression of renal injury in diabetes. The results of the present study are encouraging for its potential use to delay the onset and progression of diabetic renal complications. However, the translation of therapeutic efficacy in humans requires further studies.
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