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Zebra fish as an efficient model for study of Salmonella infection, transmission and vaccine efficacy
8th Indo Global summit and Expo on Vaccines, Therapeutics & Healthcare
November 02-04, 2015 HICC, Hyderabad, India
Poushali Ghosh1, Debaki Ranjan Howlader1, Nilanajana Majumdar1, Dhrubajyoti Nag1, Priyadarshini Mukherjee1, Ritam Sinha1, Jeffrey Howard Withey2 and Hemanta Koley1
1National Institute of Cholera and Enteric Diseases, India 2Wayne State University School of Medicine, USA
Posters-Accepted Abstracts: J Vaccines Vaccin
Abstract:
Salmonella-induced diarrhea is one of the deadliest diseases of mankind and live-stocks. Here, we have selected a natural animal model of Salmonella-infection, zebra-fish. Zebra-fishes are indigenous to the Himalayan region and the rate of occurrence of the diseases relating to Salmonella is high in that area, especially in developing countries. Exposure of the zebrafishes with Salmonella enterica causes infection in the fishes without any manipulation and transmits the pathogen into the naive fishes from one to another. After successive triple oral bath vaccination with heat killed single serotype of S. typhimurium immunogen in zebra-fishes showed protective efficacy against lethal dose of heterologous strain of S. typhimurium and also blocks the transmission. This study provides a natural infection model of Salmonella enterica for the study of Salmonella enteric colonization, transmission and protective efficacy.
Biography :
Poushali Ghosh obtained her Bachelors of Technology in Biotechnology from West Bengal University of Technology and Masters of Technology in Biotechnology from Vellore Institute of Technology, Tamil Nadu. She has been working as a summer project trainee in National Institute of Cholera and Enteric Diseases, Kolkata.
Email: poush.gh@gmail.com