alexa Zebrafish As An Animal Model To Study Renal Regeneration After Acute Kidney Injury
ISSN: 2161-1025

Translational Medicine
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

3rd International Conference on Translational Medicine
November 03-05, 2014 Las Vegas, USA

Rebecca A Wingert
Accepted Abstracts: Transl Med
DOI: 10.4172/2161-1025.S1.014
Acute kidney injury (AKI) is a devastating and often lethal condition in which kidney nephron cells are destroyed by damage from ischemia or toxin exposure. While nephron epithelial cells can regenerate after some forms of damage, there is a poor understanding of the cellular and molecular events that mediate nephron regeneration. The zebrafish is an attractive and viable system to study the molecular pathways responsible for nephron regeneration, as its nephrons are simple, yet they maintain the biological complexity inherent to that of higher organisms including mammals. Previous studies have demonstrated that gentamicin-based chemical injury in zebrafish mimics human AKI, but detailed analysis of the cellular events associated with damage was not reported. We generated a novel toolkit of cellular and molecular protocols to perform this analysis in the zebrafish. Next, we extensively characterized the cellular changes resulting from gentamicin injury in the adult zebrafish using our platform of histology and immunohistochemistry techniques. This work has established the timing of renal cell death after injury, identified proliferative compartments within the kidney, and led to the assessment of gene expression changes associated with the regenerative response of proliferating cells. Taken together, these data have provided a greater understanding of the full cycle of regenerative events. Insights from this work can be applied in future translational studies toward the design of chemical genetics screens in the adult and/or embryonic zebrafish to identify renal regeneration pathways and provide novel insights into the signals that orchestrate kidney epithelial regeneration.
image PDF   |   image HTML
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version