alexa 11C-choline PET CT and MRI in Patients With multiparametric biochemical relapse of prostate cancer


Journal of Cancer Diagnosis

Author(s): JR Garcia, N Romera, M Cozar, M Soler, M Moragas

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To ASSESS the diagnostic usefulness of 11 C-choline PET / CT vs. multi-parametric MRI in the prostate cancer relapse. A retrospective study of 21 Patients Treated With INITIALLY With prostate cancer surgery (n=12), radiotherapy (n=9). Increased PSA levels Were (post-surgery: .3-3.6ng / ml; post-radiotherapy: 2.4-8.8ng / ml). In an interval of time of 15 days all Were Patients underwent to: whole-body dual-modality PET-CT Carried out early-after 11 C-choline (296±29MBq) injection, and multiparametric MRI prostate With intravenous paramagnetic contrast (using anatomical imaging sequences, diffusion-weighted imaging and dynamic contrast-enhanced imaging). On the basis of our results, all Patients underwent Were directed to diagnosis and / or clinical, analytic and imaging follow-up. In 15 Patients (71.4%) concordant results Showed Both Procedures: 4 negative and 11 positive cases [7 Recurrences Local, 3 isolated pelvic lymph nodes (2 infracentimetric), 1 Local relapse and only one bone metastases M1]. The results Were discordant in 6 Patients (28.6%): 3 Local relapses in MRI With no significance PET 1 Local relapse in PET With MRI no significance. 2 bone metastases Were Identified with pet (out of the field-of-view of MRI)

This article was published in Spanish Urological records and referenced in Journal of Cancer Diagnosis

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