alexa 1,3-Diphenylpyrazoles: synthesis and antiparasitic activities of azomethine derivatives.


Chemical Sciences Journal

Author(s): Rathelot P, Azas N, ElKashef H, Delmas F, Di Giorgio C,

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Abstract 1,3-Diphenylpyrazole-4-carboxaldehyde and 1-(4-nitrophenyl)-3-phenylpyrazole-4-carboxaldehyde were obtained from the appropriated phenylhydrazones via the Vilsmeier-Haack reaction. These two aldehydes were functionalized by various substituted anilines or substituted benzylamines. Antiparasitic activities of the corresponding azomethines were assessed. In the most cases, nitrated compounds were found to be more efficient than non-nitrated ones against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum.
This article was published in Eur J Med Chem and referenced in Chemical Sciences Journal

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