alexa 16-Gy Low-Voltage X-ray Irradiation Followed by As-Needed Ranibizumab Therapy for AMD: 6-Month Outcomes of a “Radiation-First” Strategy


Journal of Clinical & Experimental Ophthalmology

Author(s): Moshfeghi AA, Canton VM, QuirozMercado H, VelezMontoya R, LopezMiranda MJ

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BACKGROUND AND OBJECTIVE: To describe the effect of a “radiation-first” combination treatment strategy for neovascular age-related macular degeneration (AMD) with ranibizumab rescue therapy.PATIENTS AND METHODS: Non-invasive, externally delivered low-voltage x-ray irradiation at a dose of 16 Gy was given in a single session through three locations in the inferior pars plana in a consecutive series of patients with neovascular AMD. Ranibizumab was administered according to prospectively determined criteria. RESULTS: Thirteen patients completed a 6-month follow-up. All patients lost 15 or fewer ETDRS letters, 7 gained 0 or more ETDRS letters, and 0 gained more than 15 ETDRS letters. Patients received a total of 15 ranibizumab injections following x-ray irradiation at baseline. Two patients received no ranibizumab injections, seven patients received 1 injection, and four patients received 2 injections. CONCLUSION: Low-voltage x-ray treatment followed by ranibizumab rescue demonstrates an independent visual acuity stabilizing effect for patients with wet AMD.

This article was published in Ophthalmic Surgery, Lasers and Imaging Retina and referenced in Journal of Clinical & Experimental Ophthalmology

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