alexa 18F-FDG PET CT findings in a patient with isolated intracranial Rosai-Dorfman disease.


Journal of Clinical & Experimental Pathology

Author(s): Deshayes E

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Rosai-Dorman disease (RDD) or sinus histiocytosis with massive lymphadenopathy is a rare histiocytic disorder first described in 1969. RDD involving the central nervous system is considered to be rare, with fewer than 120 cases reported in the literature. We present a 51-year-old woman with a history of panhypopituitarism, episodic memory disturbance, and a hypothalamic tumor. Stereotaxic hypothalamic lesion biopsy showed histiocytic proliferation positive for S100 protein and CD68, but negative for CD1a, typical for RDD. ¹⁸F-FDG PET/CT 4 months later demonstrated increased hypothalamic metabolic activity.

This article was published in Clin Nucl Med and referenced in Journal of Clinical & Experimental Pathology

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