alexa 40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004.
Business & Management

Business & Management

Business and Economics Journal

Author(s): Veitenhansl M, Stegner K, Hierl FX, Dieterle C, Feldmeier H,

Abstract Share this page

This article was published in Diabetologia and referenced in Business and Economics Journal

Relevant Expert PPTs

Relevant Speaker PPTs

  • Anne Stinn
    Deciphering the crystal structure of NF-CU - a novel bispecific antibody for the treatment of acute myeloid leukemia
    PPT Version | PDF Version
  • A K Sreekala
    Floral structure in relation to pollination and breeding system of selected endemic Impatiens of Western Ghats
    PPT Version | PDF Version
  • Albert Owusu
    Albert-Owusu-Bana-Consulting-Engineers-Australia-Rethinking-the-Application-of-Engineering-Structural-Analysis-of-Economic-Impact-Risk-Propagation-in-Infra-structures
    PPT Version | PDF Version
  • M.Manikandan
    M-Manikandan-Gulf-Consult-Kuwait-Design-and-Behavior-of-Steel-Structure’s-from-Constructability-Perspectives
    PPT Version | PDF Version
  • Zuheir Barsoum
    Zuheir-Barsoum-Khalifa-University-UAE-Life-extension-upgrade-and-repair-of-welded-structures-Towards-the-use-of-High-Strength-Steels
    PPT Version | PDF Version
  • Osama O. Ibrahim
    Chemicals structure, properties, regulations and applications of non-nutritive-high intensity sweeteners
    PDF Version
  • Jianbo Wang
    Transcriptome and small RNA gene expression changes in synthetic allohexaploids of
    PPT Version | PDF Version
  • Yosef Yarden
    Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
    PPT Version | PDF Version
  • Kevin R. Anderson
    Kevin-Anderson-California-State-Polytechnic-University-USA-Fluid-Structure-interaction-(FSI)-analysis-of-a-solar-powered-UAV
    PPT Version | PDF Version
  • Ewa Maj
    Antiangiogenic treatment in non-small cell lung cancer (NSCLC)
    PPT Version | PDF Version
  • Isabel Martín
    Sustainable water reuse. The case of rural areas and small settlements
    PPT Version | PDF Version
  • Sanjay Parashar
    Structured analysis of nose to achieve natural results in rhinoplasty
    PPT Version | PDF Version
  • R Mala
    Fabrication of nano structured PGPR mediated slow release fertilizer system and its influence on germination of Arachis hypogea
    PPT Version | PDF Version
  • S Karthikeyan
    Resveratrol modulates expression of ABC transporters in non-small lung cancer cells: Molecular docking and gene expression studies
    PPT Version | PDF Version
  • Yamina Andre
    Nanostructured self-assembled P3HT thin films and their application to enhance organic solar cell efficiency
    PPT Version | PDF Version
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords