Author(s): Ehrenschwender T, Wagenknecht HA
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Abstract 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) as a fluorescent label can be incorporated into DNA by two conceptually different ways: the non-nucleosidic DNA base surrogate Bo exhibits high brightness but no preferential base-pairing properties, whereas the BODIPY-modified uridine BodU has reduced quantum yields but shows preferred Watson-Crick base pairing with adenine.
This article was published in J Org Chem
and referenced in Journal of Bioanalysis & Biomedicine