alexa 9-Benzylpurines with inhibitory activity against Mycobacterium tuberculosis.


Medicinal Chemistry

Author(s): Bakkestuen AK, Gundersen LL, Langli G, Liu F, Nolse JM

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Abstract 9-Benzylpurines with a variety of substituents in the 2-, 6- and/or 8-position have been prepared and screened for antimycobacterial effects. High inhibitory activity against Mycobacterium tuberculosis was found for 9-benzylpurines carrying a phenylethynyl-, trans-styryl or aryl substituents in the 6-position and generally chlorine in the 2-position tends to increase activity.
This article was published in Bioorg Med Chem Lett and referenced in Medicinal Chemistry

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