alexa A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism.


Journal of Microbial & Biochemical Technology

Author(s): Rogers SA, Huigens RW rd, Melander C

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Abstract A number of 2-aminobenzimidazole derivatives were synthesized and screened for their ability to inhibit and disperse bacterial biofilms. From these compounds, a lead 2-aminobenzimidazole was identified that both inhibited and dispersed MRSA, vancomycin-resistant Enterococcus faecium, and Staphylococcus epidermidis biofilms. Mechanistic studies showed that the activity is Zn(II)-dependent, potentially via a direct zinc-chelating mechanism. This article was published in J Am Chem Soc and referenced in Journal of Microbial & Biochemical Technology

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