alexa A Basis for Rapid Clearance of Circulating Ring-Stage Malaria Parasites by the Spiroindolone KAE609.
Infectious Diseases

Infectious Diseases

Malaria Control & Elimination

Author(s): Zhang R, Suwanarusk R, Malleret B, Cooke BM, Nosten F,

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Abstract Recent clinical trials revealed a surprisingly rapid clearance of red blood cells (RBCs) infected with malaria parasites by the spiroindolone KAE609. Here, we show that ring-stage parasite-infected RBCs exposed to KAE609 become spherical and rigid, probably through osmotic dysregulation consequent to the disruption of the parasite's sodium efflux pump (adenosine triphosphate 4). We also show that this peculiar drug effect is likely to cause accelerated splenic clearance of the rheologically impaired Plasmodium vivax- and Plasmodium falciparum-infected RBCs. © The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America.
This article was published in J Infect Dis and referenced in Malaria Control & Elimination

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