alexa A blast from the past: clearance of apoptotic cells regulates immune responses.


Journal of Clinical & Cellular Immunology

Author(s): Savill J, Dransfield I, Gregory C, Haslett C

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Abstract Apoptosis, which is a programmed and physiological form of cell death, is known to shape the immune system by regulating populations of effector lymphocytes. However, the binding and ingestion of dying cells by monocytes/macrophages and dendritic cells can also influence immune responses markedly by enhancing or suppressing inflammation. Therefore, dead cells, which are a reflection of an organism's immediate past, can control its immunological future. This article was published in Nat Rev Immunol and referenced in Journal of Clinical & Cellular Immunology

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