alexa [A case of myopathy with ulcerative colitis].
Medicine

Medicine

Internal Medicine: Open Access

Author(s): Hasegawa H, Hasegawa K, Saito T, Kowa H, Nonaka I

Abstract Share this page

Abstract A 41-year-old woman was admitted to a local hospital because of bloody diarrhea and diagnosed as having ulcerative colitis (UC). Despite prednisolone of 40 mg/day administration, her symptoms aggravated rapidly and she developed muscle weakness of lower limbs two weeks after steroid administration. On admission, she was bed-ridden and could not lift her knees and arms from bed. The serum CK level was increased slightly and total protein decreased markedly. She had moderate liver dysfunction, mild hyperthyroidism, mild glucose intolerance, and some results suggestive of immuno-deficiency including positive cold agglutinin and microsome tests, and positive antinuclear antibody. Her muscle biopsy showed both type 1 and 2 fiber atrophy and focal myofibrillar degeneration with autophagic phenomenon. There were a few fibers with nemaline bodies probably formed from marked degeneration of myofibrils. Although she had been on prednisolone for 2 weeks, the degenerative muscle pathology differed from that of steroid myopathy in which type 2 fiber atrophy is one of characteristic findings. Some additional factors including marked malnutrition, possible immuno-deficiency and hyperthyroidism should be considered for the pathogenesis of this particular myopathic changes. Since her general condition and muscle weakness gradually improved postoperatively, UC itself might have played an important role in inducing muscle symptoms.
This article was published in Rinsho Shinkeigaku and referenced in Internal Medicine: Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 22nd World Cardiology Conference
    December 11-12, 2017 Rome, Italy

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords