alexa A case of ovarian hyperstimulation syndrome associated with the methylenetetrahydrofolate reductase mutation gene
Reproductive Medicine

Reproductive Medicine

Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biology

Author(s): Ferrara F, Meli F, Amato C

Abstract Share this page

OBJECTIVE:

To report a case of ovarian hyperstimulation syndrome with methylenetetrahydrofolate reductase (MTHFR) gene 677T homozygosis mutation and A1298C gene heterozygosis mutation.

DESIGN:

Case report.

SETTING:

A pregnant woman in an academic hospital.

PATIENT(S):

A woman with ovarian hyperstimulation syndrome.

INTERVENTION(S):

Nadroparin was administered for 2 weeks at a dosage of 200 IU/kg twice per day and then once per day; also administered once per day were folates, 5 mg; B6 vitamin, 15 mg; and B12 vitamin, 1 mg.

MAIN OUTCOME MEASURE(S):

Clinical follow-up.

RESULT(S):

Delivery was regular within the set time limits, and the fetus was born alive and in good health.

CONCLUSION(S):

We believe that MTHFR mutation research could be executed in women before ovarian stimulation treatment, but other observations are necessary to support this recommendation.

This article was published in Fertil Steril and referenced in Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biology

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