alexa A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis.
Pharmaceutical Sciences

Pharmaceutical Sciences

Biochemistry & Pharmacology: Open Access

Author(s): Tanaka A, Youle RJ

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Abstract DRP1, a member of the dynamin family of large GTPases, mediates mitochondrial fission. In a recent issue of Developmental Cell, Cassidy-Stone et al. (2008) identified mdivi-1, a new DRP1 inhibitor that prevents mitochondria division and Bax-mediated mitochondrial outer membrane permeabilization during apoptosis. This article was published in Mol Cell and referenced in Biochemistry & Pharmacology: Open Access

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