alexa A Comparison of determination of related substances in risperidone tablets by HPLC and UPLC
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): YAN Xiaodan, GAO Ming, CAI Zhenhua

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Objective To compare the methods for determination of related substances in risperidone tablets.Methods We determinated the related substances in risperidone tablets by HPLC and UPLC respectively and compared the separation,specificity,linear range,sensitivity,precision and the impurity contents of samples by the two methods.Several risperidone tablets from different manufacturers were determined by HPLC and UPLC.Results The analysis time of UPLC was obviously shorter than that of HPLC.There were no significant differences among separation,linear range,and precision.UPLC was more sensitive than HPLC.The determination results of samples by two methods were close,while those determined by HPLC were lower.Conclusion UPLC improves the analysis efficiency,with higher resolution,which is the ideal choice of quick analysis.

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This article was published in Anhui Medical and Pharmaceutical Journa and referenced in Journal of Chromatography & Separation Techniques

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