alexa A confirmatory study of the up-and-down method for acute oral toxicity testing.


Biochemistry & Analytical Biochemistry

Author(s): Bruce RD

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Abstract Ten materials have been tested in parallel both by the "classical" method for acute oral toxicity (LD50) and by the up-and-down method. Materials tested included laundry and dishwashing detergents, a shampoo, a flavor, potassium hydroxide, and caffeine. All testing was done in Sprague-Dawley rats. Excellent agreement was seen between the two methods. The classical method typically used 40 to 50 animals while the up-and-down method required only six to nine animals per material.
This article was published in Fundam Appl Toxicol and referenced in Biochemistry & Analytical Biochemistry

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