Author(s): Barkovich AJ, Guerrini R, Kuzniecky RI, Jackson GD, Dobyns WB, Barkovich AJ, Guerrini R, Kuzniecky RI, Jackson GD, Dobyns WB
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Abstract Malformations of cerebral cortical development include a wide range of developmental disorders that are common causes of neurodevelopmental delay and epilepsy. In addition, study of these disorders contributes greatly to the understanding of normal brain development and its perturbations. The rapid recent evolution of molecular biology, genetics and imaging has resulted in an explosive increase in our knowledge of cerebral cortex development and in the number and types of malformations of cortical development that have been reported. These advances continue to modify our perception of these malformations. This review addresses recent changes in our perception of these disorders and proposes a modified classification based upon updates in our knowledge of cerebral cortical development.
This article was published in Brain
and referenced in Journal of Neurology & Neurophysiology