Author(s): Siamaki AR, Arndtsen BA
Abstract Share this page
Abstract A palladium-catalyzed one-step synthesis of imidazoles from imines and acid chlorides is described. A plausible mechanism for this multicomponent reaction is provided, which explains the selective incorporation of two different imines into the final product with perfect regiocontrol. Overall, this catalytic process provides a modular method to prepare imidazoles directly from building blocks that are all either commercially available or readily generated.
This article was published in J Am Chem Soc
and referenced in Organic Chemistry: Current Research