alexa A facile route to paclitaxel C-10 carbamates.
Materials Science

Materials Science

Journal of Nanomedicine & Nanotechnology

Author(s): Ballatore C, Aspland SE, Castillo R, Desharnais J, Eustaquio T,

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Abstract A general protocol for the synthesis of paclitaxel C-10 carbamates is described. The method entails MeI-mediated activation of 2'-O-TBS-7-O-TES-10-O-deacetyl-paclitaxel-10-O-carbonylimidazole prior to reaction with amines. This method is effective for the synthesis of paclitaxel C-10 derivatives, including bifunctional molecules. This article was published in Bioorg Med Chem Lett and referenced in Journal of Nanomedicine & Nanotechnology

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