Author(s): Bates CG, Gujadhur RK, Venkataraman D
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Abstract [reaction: see text] We report a mild, palladium-free synthetic protocol for the cross-coupling reaction of aryl iodides and thiols using 10 mol \% CuI and 10 mol \% neocuproine, with NaOt-Bu as the base, in toluene at 110 degrees C. Using this protocol, we have shown that a variety of aryl sulfides can be synthesized in excellent yields from readily available iodides and thiols.
This article was published in Org Lett
and referenced in Organic Chemistry: Current Research