alexa A low resolution structure for the histone core of the nucleosome.
Medicine

Medicine

Journal of Gerontology & Geriatric Research

Author(s): Klug A, Rhodes D, Smith J, Finch JT, Thomas JO

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Abstract Image reconstruction to 22 A resolution of the histone octamer (H3)2(H4)2(H2A)2(H2B)2 shows it to have a 2-fold axis of symmetry, and the overall shape of the left-handed helical spool on which to wind about two turns of a flat superhelix of DNA in the nucleosome. From this structure and the results of various cross-linking studies, we have deduced the arrangement of the individual histones. We propose that the (H3)2(H4)2 tetramer forms a dislocated disk which defines the central turn of DNA, while the two H2A-H2B dimers lie one on each face, each associated with about one half a turn.
This article was published in Nature and referenced in Journal of Gerontology & Geriatric Research

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