alexa A low-cost miniaturized potentiostat for point-of-care diagnosis.
Engineering

Engineering

Journal of Biosensors & Bioelectronics

Author(s): Cruz AF, Norena N, Kaushik A, Bhansali S

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Abstract This paper presents a novel approach of using a miniaturized potentiostat (M-P) chip (LMP91000) to perform full range cyclic voltammetry (CV) measurements for the detection of biomarkers. The LMP91000 evaluation board was reconfigured to perform three-electrode CV measurements in order to achieve electrochemical cortisol immunosensing. The microelectrodes for cortisol estimation were fabricated by immobilizing monoclonal anti-cortisol antibody (Anti-M-Cab) onto self-assembled monolayer (SAM) modified Au microelectrodes. The results obtained using the M-P were compared to those obtained using a conventional potentiostat. The M-P was successful in measuring cortisol levels in the range of pM. The outcomes of the studies suggest that M-P can effectively perform biochemical measurements on three electrode systems, enabling the development of miniature systems for point-of-care (POC) diagnosis. Copyright © 2014. Published by Elsevier B.V. This article was published in Biosens Bioelectron and referenced in Journal of Biosensors & Bioelectronics

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