Author(s): Rosen LB, Williams WD, Benson J, Rywlin AM
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Abstract A case of a malignant neoplasm with features suggestive of both malignant melanoma and squamous cell carcinoma is reported. The neoplastic cells were positive for both S-100 protein and keratin when stained by the indirect peroxidase-antiperoxidase method. The literature on other instances of bi- or multidirectional differentiation of neoplastic cells is reviewed. The significance of these findings for terminology of neoplasms is discussed.
This article was published in Am J Dermatopathol
and referenced in Journal of Pigmentary Disorders