alexa A meta-analysis of erythropoiesis-stimulating agents in anaemic patients with chronic heart failure.
Cardiology

Cardiology

Journal of Clinical & Experimental Cardiology

Author(s): Jin B, Luo X, Lin H, Li J, Shi H

Abstract Share this page

Abstract AIMS: Anaemia is a frequent comorbidity in patients with chronic heart failure (CHF) and is associated with worse outcomes. It is logical to consider whether correcting anaemia is a novel therapeutic target in such patients. We performed a meta-analysis to explore whether treatment of anaemia with erythropoietin-stimulating agents (ESA) can improve symptoms and progression in patients with CHF. METHODS AND RESULTS: Studies were identified in English-language articles by searching PUBMED (inception to May 2009). A standardized protocol with predefined criteria was used to extract details on study design, Jadad score, demographic data, interventions, and outcomes. The main outcome measures were cardiac function, exercise capacity, quality of life, and all-cause mortality. Seven randomized controlled trials involving 678 patients were identified and included in the analysis. Cardiac function as well as exercise capacity were improved post-treatment in the ESA group; however, the overall deaths analysis demonstrated a lower trend but no significant protective effect in the ESA treatment group (RR, 0.71; 95\% confidence interval, 0.41-1.24; P = 0.23). CONCLUSION: This meta-analysis suggests a symptomatic improvement in anaemic patients with CHF receiving ESA. However, a non-significant reduction in all-cause mortality in the ESA treatment group compared with the control group was observed. This article was published in Eur J Heart Fail and referenced in Journal of Clinical & Experimental Cardiology

Relevant Expert PPTs

Relevant Speaker PPTs

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords