Author(s): Hussain R, Buscombe JR
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Abstract BACKGROUND: Scintimammography using (99m)Tc-labelled isonitriles, sestamibi and tetrofosmin, has become a mature technique in the adjunctive setting for the diagnosis of primary breast cancer. To establish an evidence base for its use, clinically, a meta-analysis was performed on both single-site and multi-centre trials performed since January 1997. METHODS: Using an on-line literature search all such trials containing 100 or more studies were identified. To prevent double counting of patients only the last published report from any centre was used. RESULTS: A total of 2424 patients were identified in the single-site trial group, the smallest study having 105 patients and the largest 353 patients. The overall sensitivity was 85\% and the specificity was 84\%. In the multi-centre trial studies, published data from 3049 patients were included. The overall sensitivity in this group was also 85\% and the specificity was 83\%. CONCLUSION: There is evidence that this is a robust imaging technique delivering high sensitivities and specificities in patients studied in both single-centre and multi-centre trials and, as such, can be relied on as an adjunctive method for the investigation of primary breast cancer.
This article was published in Nucl Med Commun
and referenced in Journal of Cancer Science & Therapy