alexa A method for preparing an aqueous colloidal dispersion of organic materials by using water-soluble polymers: Dispersion of beta-carotene by polyvinyl pyrrolidone
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Pharmacovigilance

Author(s): Taro Tachibana, Akio Nakamura

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A new method was developed for preparing an aqueous colloidal dispersion ofΒ-carotene. This method consists of preparing a solid mixture ofΒ-carotene and polyvinylpyrrolidone (PVP) from their chloroform solution by evaporating the solvent and dissolving the mixture into water. From filtration experiment and electron microscopic observation it was found thatΒ-carotene in its aqueous dispersion exists as colloidal particles with a diameter of about 100 å. Spectroscopic data evidenced thatΒ-carotene is molecularly dispersed in solid of PVP. It was considered that PVP acts as a solid solvent forΒ-carotene and, at the same time, a stabilizing agent for its aqueous dispersion. Instead of PVP, such a hydrophilic-oleophilic substance as methylcellulose, polyvinylmethylether or Aerosol OT could be also used as the dispersing agent. Other materials thanΒ-carotene could be dispersed by similar technique.

  • Open Access
This article was published in Kolloid-Z Polym and referenced in Journal of Pharmacovigilance

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