alexa A neural circuit framework for somatosensory amplification in somatoform disorders.
Psychiatry

Psychiatry

Journal of Psychology & Psychotherapy

Author(s): Perez DL, Barsky AJ, Vago DR, Baslet G, Silbersweig DA

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Although somatosensory amplification is theorized to serve a critical role in somatization, it remains poorly understood neurobiologically. In this perspective article, convergent visceral-somatic processing is highlighted, and neuroimaging studies in somatoform disorders are reviewed. Neural correlates of cognitive-affective amplifiers are integrated into a neurocircuit framework for somatosensory amplification. The anterior cingulate cortex, insula, amygdala, hippocampal formation, and striatum are some of the identified regions. Clinical symptomatology in a given patient or group may represent dysfunction in one or more of these neurobehavioral nodes. Somatosensory amplification may, in part, develop through stress-mediated aberrant neuroplastic changes and the neuromodulatory effects of inflammation.

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This article was published in J Neuropsychiatry ClinNeurosci and referenced in Journal of Psychology & Psychotherapy

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