alexa A note on exact conditional and unconditional tests for Hardy-Weinberg equilibrium.
Mathematics

Mathematics

Journal of Biometrics & Biostatistics

Author(s): Shan G

Abstract Share this page

Abstract The exact conditional approach is frequently used for testing Hardy-Weinberg equilibrium in population genetics. This approach respects the test size as compared to the traditionally used asymptotic approaches. It is a full-enumeration method and very computational. Many efficient algorithms have been successfully developed to implement this exact approach. An alternative to the conditional approach is the unconditional approach, which relaxes the restriction of the fixed number of allelic counts as in the conditional approach. The first unconditional test considered in this study is the one based on maximization, which has been shown to be more powerful than the conditional test to loci with two alleles for small sample sizes. By using the p value of the conditional approach as a test statistic in the following maximization step, the second unconditional test is uniformly more powerful than the conditional approach. We compared these exact tests based on three commonly used test statistics with regards to type I error rate and power. It is recommended to use the second unconditional approach in practice due to the power gain in the case with two alleles. This article was published in Hum Hered and referenced in Journal of Biometrics & Biostatistics

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords