Author(s): Deshmukh MB, Salunkhe SM, Patil DR, Anbhule PV
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Abstract The first simple and efficient approach towards one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines has been developed by three component condensation of aromatic aldehydes, ethyl cyanoacetate and guanidine hydrochloride in alkaline ethanol. The synthesized compounds evaluated for their anti-bacterial activity against gram-positive and gram-negative bacteria. The some of the compounds showed excellent zone of inhibition against tested bacteria.
This article was published in Eur J Med Chem
and referenced in Journal of Proteomics & Bioinformatics