alexa A novel test for testing the optimally weighted combination of rare and common variants based on data of parents and affected children.
Genetics & Molecular Biology

Genetics & Molecular Biology

Human Genetics & Embryology

Author(s): Sha Q, Zhang S

Abstract Share this page

Abstract With the development of sequencing technologies, the direct testing of rare variant associations has become possible. Many statistical methods for detecting associations between rare variants and complex diseases have recently been developed, most of which are population-based methods for unrelated individuals. A limitation of population-based methods is that spurious associations can occur when there is a population structure. For rare variants, this problem can be more serious, because the spectrum of rare variation can be very different in diverse populations, as well as the current nonexistence of methods to control for population stratification in population-based rare variant associations. A solution to the problem of population stratification is to use family-based association tests, which use family members to control for population stratification. In this article, we propose a novel test for Testing the Optimally Weighted combination of variants based on data of Parents and Affected Children (TOW-PAC). TOW-PAC is a family-based association test that tests the combined effect of rare and common variants in a genomic region, and is robust to the directions of the effects of causal variants. Simulation studies confirm that, for rare variant associations, family-based association tests are robust to population stratification although population-based association tests can be seriously confounded by population stratification. The results of power comparisons show that the power of TOW-PAC increases with an increase of the number of affected children in each family and TOW-PAC based on multiple affected children per family is more powerful than TOW based on unrelated individuals. © 2013 WILEY PERIODICALS, INC.
This article was published in Genet Epidemiol and referenced in Human Genetics & Embryology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version