alexa A partially folded structure of amyloid-beta(1-40) in an aqueous environment.
Nephrology

Nephrology

Journal of Nephrology & Therapeutics

Author(s): Vivekanandan S, Brender JR, Lee SY, Ramamoorthy A

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Abstract Aggregation of the Aβ(1-40) peptide is linked to the development of extracellular plaques characteristic of Alzheimer's disease. While previous studies commonly show the Aβ(1-40) is largely unstructured in solution, we show that Aβ(1-40) can adopt a compact, partially folded structure. In this structure (PDB ID: 2LFM), the central hydrophobic region of the peptide forms a 3(10) helix from H13 to D23 and the N- and C-termini collapse against the helix due to the clustering of hydrophobic residues. Helical intermediates have been predicted to be crucial on-pathway intermediates in amyloid fibrillogenesis, and the structure presented here presents a new target for investigation of early events in Aβ(1-40) fibrillogenesis. Copyright © 2011 Elsevier Inc. All rights reserved.
This article was published in Biochem Biophys Res Commun and referenced in Journal of Nephrology & Therapeutics

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