alexa A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis.


Journal of Clinical & Cellular Immunology

Author(s): Huseby ES, Liggitt D, Brabb T, Schnabel B, Ohln C,

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Abstract Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) characterized by plaques of infiltrating CD4(+) and CD8(+) T cells. Studies of MS and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, focus on the contribution of CD4(+) myelin-specific T cells. The role of CD8(+) myelin-specific T cells in mediating EAE or MS has not been described previously. Here, we demonstrate that myelin-specific CD8(+) T cells induce severe CNS autoimmunity in mice. The pathology and clinical symptoms in CD8(+) T cell-mediated CNS autoimmunity demonstrate similarities to MS not seen in myelin-specific CD4(+) T cell-mediated EAE. These data suggest that myelin-specific CD8(+) T cells could function as effector cells in the pathogenesis of MS.
This article was published in J Exp Med and referenced in Journal of Clinical & Cellular Immunology

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