alexa A physiological view and structures of mean residence times.
Toxicology

Toxicology

Journal of Drug Metabolism & Toxicology

Author(s): Duriov M

Abstract Share this page

Abstract The author's previous theoretical study described the determination of a physiologically realistic structure of a mean residence time of an intravenously administered drug (Ďurišová 2012). This study continues previous work and the aim is to determine physiologically realistic structures of mean residence times of a drug administered either orally (MRTpo) or intramuscularly (MRTim). The determinations are based on the following assumption: a cardiopulmonary, portal, portal-venous, hepatic-portal subsystem, and a subsystem that mathematically represents non-eliminating tissues can be considered to be most important in terms of their impact on MRTpo and MRTim. If drug fate and disposition is a linear process, the used method allows developing mathematical models without any prior knowledge or hypothesis concerning drug fate and disposition. This is a great advantage of the method considered here when compared with compartment methods. The research presented in this study was aimed at contributing to the knowledge base of physiological origins of mean residence times. This article was published in Gen Physiol Biophys and referenced in Journal of Drug Metabolism & Toxicology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords