alexa A possible "universal" cancer vaccine that might cause an immune response against emerging cancer cells that originate from any tissue.


Clinical Depression

Author(s): Corocleanu M

Abstract Share this page

Abstract Since an ongoing interaction between a potential cancer cell and its microenvironment is a necessary requirement for their co-evolution towards a malignant disease state, a future success of cancer prevention will depend on how effectively a vaccination strategy simultaneously acts on emerging pretumor cells as well as on its microenvironment. Based on the assumption and theory that a placental vaccine could induce humoral and cell-mediated immune response against both the embryo-like antigens and angiogenic factors that are common to placental and cancer cells, this vaccination would create an immunological state in normal healthy individuals which would result in rejection of foreign nascent transforming cells, or cancer initiating cells (so called cancer stem cells). Immunoplacental Vaccine (Human placenta whole cell lysates) prepared upon Filatov's method, consisting of heat shock proteins and associated placental peptide complexes-version of homologous non-mutated proteins that are found on different kinds of epithelial cancer cells, when intradermal coinjected with an adjuvant, i.e. BCG-Vaccine, in normal healthy individuals, may function as a multi-epitope vaccine; the body recognizes the placental antigens of this vaccine as foreign, and thus stimulates a cross-reactive humoral and cell-mediated immune response targeting cancer tumor-associated antigens (TAA), as well as proteins that aid in cancer development. Also, by eliciting of critical cytokines at the vaccination site may result in cytokine-network balancing and in promoting Th1 cell-mediated immunity in the local microenvironment of preneoplastic to neoplastic transformation. Thus, this vaccination approach, by fine-tuning T-cell repertoire, T-cell regulation and cytokine-network balancing in the local microenvironment of preneoplastic to neoplastic transformation, acts on both "abnormal cells" and their "abnormal microenvironment", in which abnormal clones develop. This article was published in Med Hypotheses and referenced in Clinical Depression

Relevant Expert PPTs

Relevant Speaker PPTs

  • Enrique M. Ostrea
    Alluvial and riparian soils as major sources of lead exposure in young children in the Philippines: The role of floods
    PPT Version | PDF Version
  • Pilar Montesó Curto
    Diagnosed, Identified, Current and Complete Depression Among Patients Attending Primary Care in Southern Catalonia: Different Aspects of the Same Concept
    PPT Version | PDF Version
  • Yosef Yarden
    Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
    PPT Version | PDF Version
  • Sahreen Malik Bhanji
    Social determinants of depression among HIV positive patients in Karachi, Pakistan
    PPT Version | PDF Version
  • Hui-Mei Chen
    Randomised Controlled Trial on the Effectiveness of Home-Based Walking Exercise on Depression in Patients with Lung Cancer
    PPT Version | PDF Version
  • Heather MacDonald
    Removing the mask: Women returning to work after a lapse due to depression
    PPT Version | PDF Version
  • Heather Mac Donald
    Battling adversity: Women’s journey back to work after a lapse due to depression
    PPT Version | PDF Version
  • Marcelo Febo
    3,4-Methylenedioxypyrovalerone (MDPV), a major bath salt drug, reduces functional connectivity in rat brain
    PPT Version | PDF Version

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version