alexa A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.
Reproductive Medicine

Reproductive Medicine

Reproductive System & Sexual Disorders: Current Research

Author(s): Rosner MH, Vigano MA, Ozato K, Timmons PM, Poirier F,

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Abstract The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes, oct-3 is expressed in the totipotent and pluripotent stem cells of the pregastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line. This article was published in Nature and referenced in Reproductive System & Sexual Disorders: Current Research

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