alexa A quantum dot conjugated sugar ball and its cellular uptake. On the size effects of endocytosis in the subviral region.
Materials Science

Materials Science

Journal of Nanomedicine & Nanotechnology

Author(s): Osaki F, Kanamori T, Sando S, Sera T, Aoyama Y

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Abstract The lipophilic CdSe quantum dot (QD) coated with trioctylphosphine oxide (TOPOQD) can be extracted from chloroform into water upon interaction with macrocyclic glycocluster amphiphile 1. The QD-conjugated and highly fluorescent sugar ball of a size of 15 nm (TOPOQD1) thus solubilized in water readily invades Hela cells via endocytosis. The endocytic activity of TOPOQD1 (15 nm), in light of those of the micellar homoaggregate of 1 (5 nm) and the virus-like 1-DNA conjugate (50 nm) as references, reveals a dramatic size effect (50 > 15 > 5) in the subviral size region. The optimal size at approximately 50 nm indicates that size complementarity which governs molecular recognition in small host-guest systems also plays key roles in the encapsulation of nanometric guest particles by the endocytic vesicles (
  • DOI: 10.1021/ja048792a
  • This article was published in J Am Chem Soc and referenced in Journal of Nanomedicine & Nanotechnology

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