alexa A randomised, 52-week, treat-to-target trial comparing insulin detemir with insulin glargine when administered as add-on to glucose-lowering drugs in insulin-naive people with type 2 diabetes.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Rosenstock J, Davies M, Home PD, Larsen J, Koenen C, , Rosenstock J, Davies M, Home PD, Larsen J, Koenen C,

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Abstract AIMS/HYPOTHESIS: This 52-week multinational, randomised, open-label, parallel-group, non-inferiority trial compared clinical outcomes following supplementation of oral glucose-lowering drugs with basal insulin analogues detemir and glargine in type 2 diabetic patients. METHODS: Insulin-naive adults (n=582, HbA(1c) 7.5-10.0\%, BMI 7.0 mmol/l after achieving FPG <7.0 mmol/l. Due to labelling restrictions, no second glargine dose was allowed. RESULTS: Baseline HbA(1c) decreased from 8.6 to 7.2 and 7.1\% (NS) with detemir and glargine, respectively. FPG improved from 10.8 to 7.1 and 7.0 mmol/l (NS), respectively. With detemir, 45\% of participants completed the study on once daily dosing and 55\% on twice daily dosing, with no difference in HbA(1c). Overall, 52\% of participants achieved HbA(1c) This article was published in Diabetologia and referenced in Journal of AIDS & Clinical Research

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