alexa A randomized, masked comparison of topical ketorolac 0.4\% plus steroid vs steroid alone in low-risk cataract surgery patients.
Ophthalmology

Ophthalmology

Journal of Clinical & Experimental Ophthalmology

Author(s): Wittpenn JR, Silverstein S, Heier J, Kenyon KR, Hunkeler JD,

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Abstract PURPOSE: To evaluate whether adding perioperative topical ketorolac tromethamine 0.4\% improves cataract surgery outcomes relative to topical steroids alone in patients without known risk factors for cystoid macular edema (CME). DESIGN: Prospective, randomized, investigator-masked, multicenter clinical trial. METHODS: Patients scheduled to undergo phacoemulsification and with no recognized CME risks (diabetic retinopathy, retinal vascular disease, or macular abnormality) were randomized to receive either prednisolone acetate 1\% 4 times daily (QID) alone (steroid group; n = 278) or prednisolone 1\% QID plus ketorolac 0.4\% QID (ketorolac/steroid group; n = 268) for approximately four weeks postoperatively. In the ketorolac/steroid group, patients also received topical ketorolac 0.4\% QID for three days preoperatively. In both groups, patients received four doses of ketorolac 0.4\% one hour before surgery. Patients with capsular disruption or vitreous loss intraoperatively were exited from the study. Outcome measures included CME incidence, retinal thickness as measured by optical coherence tomography (OCT), best-corrected visual acuity, and contrast sensitivity. RESULTS: No patients in the ketorolac/steroid group and five patients in the steroid group had clinically apparent CME (P = .032). Based on OCT, no ketorolac/steroid patient had definite or probable CME, compared with six steroid patients (2.4\%; P = .018). In the ketorolac/steroid group, mean retinal thickening was less (3.9 microm vs 9.6 microm; P = .003), and fewer patients had retinal thickening of more than 10 microm as compared with the steroid group (26\% vs 51\%; P < .001). CONCLUSIONS: This study suggests that adding perioperative ketorolac to postoperative prednisolone significantly reduces the incidences of CME and macular thickening in cataract surgery patients already at low risk for this condition. TRIAL REGISTRATION: ClinicalTrials.gov NCT00348244. This article was published in Am J Ophthalmol and referenced in Journal of Clinical & Experimental Ophthalmology

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