alexa A reevaluation of integrins as regulators of angiogenesis.


Journal of Bone Research

Author(s): Richard O Hynes

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Pharmacological agents directed against the integrins alpha(v)beta(3) and alpha(v)beta(5) have been reported to inhibit angiogenesis. However, genetic ablations of the genes encoding these integrins fail to block angiogenesis and in some cases even enhance it. This apparent paradox suggests the hypotheses that these integrins are negative regulators of angiogenesis and that the drugs targeting them may be acting as agonists rather than antagonists.

This article was published in Nat Med. and referenced in Journal of Bone Research

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