alexa A retrospective study evaluating the use of Permacol™ surgical implant in incisional and ventral hernia repair.


Journal of Medical Implants & Surgery

Author(s): Chand B, Indeck M, Needleman B, Finnegan M, Van Sickle KR,

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Abstract BACKGROUND: The outcome of incisional and ventral hernia repair depends on surgical technique, patient, and material. Permacol™ surgical implant (crosslinked porcine collagen) has been used for over a decade; however, there are few data on outcomes. This study is the largest retrospective multinational study to date to evaluate outcomes with Permacol™ surgical implant in the repair of incisional and ventral hernias. METHODS: Data were collected retrospectively on 343 patients treated for 213 incisional and 130 ventral hernias. Data evaluated included patient demographics, wound classification, surgical technique, morbidity, and recurrence rates. RESULTS: Median follow-up time was 649 days (max: 2857), median age 57 years (range 23-91), and BMI 32 kg/m(2) (range 17.6-77.8). Two or more comorbidities were present in 70\% of patients. Open surgery was performed in 220 (64\%) patients. Permacol™ surgical implant was used as an underlay (250), sublay (39), onlay (37), or inlay (17). Surgical techniques included component separation (89; 25.9\%), modified Stoppa technique (197; 57.4\%), and Rives-Stoppa (17; 5.0\%). CDC Surgical Wound Classification was Class I (190), Class II (103), Class III (28), and Class IV (22). Complications were seen in 40.5\% (139) of the patients, with seroma (19\%) and wound infection (15\%) as the most common. Mesh removal occurred in 1 (0.3\%) patient. Kaplan-Meier analysis demonstrated that the probabilities for hernia recurrence at one, two, and three years were 5.8\%, 16.6\%, and 31.0\%, respectively. CONCLUSIONS: Permacol™ surgical implant was shown to be safe with relatively low rates of hernia recurrence. CLINICAL TRIAL REGISTRATION NUMBER: NCT01214252 ( Copyright © 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved. This article was published in Int J Surg and referenced in Journal of Medical Implants & Surgery

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