alexa A review of acetaminophen poisoning.


Journal of Drug Metabolism & Toxicology

Author(s): Hodgman MJ, Garrard AR

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Abstract Acetaminophen poisoning remains one of the more common drugs taken in overdose with potentially fatal consequences. Early recognition and prompt treatment with N-acetylcysteine can prevent hepatic injury. With acute overdose, the Rumack-Matthew nomogram is a useful tool to assess risk and guide management. Equally common to acute overdose is the repeated use of excessive amounts of acetaminophen. Simultaneous ingestion of several different acetaminophen-containing products may result in excessive dosage. These patients also benefit from N-acetylcysteine. Standard courses of N-acetylcysteine may need to be extended in patients with persistently elevated plasma concentrations of acetaminophen or with signs of hepatic injury. Copyright © 2012 Elsevier Inc. All rights reserved. This article was published in Crit Care Clin and referenced in Journal of Drug Metabolism & Toxicology

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