alexa A role for BLM in double-strand break repair pathway choice: prevention of CtIP Mre11-mediated alternative nonhomologous end-joining.
Genetics & Molecular Biology

Genetics & Molecular Biology

Gene Technology

Author(s): Grabarz A, GuirouilhBarbat J, Barascu A, Pennarun G, Genet D,

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Abstract The choice of the appropriate double-strand break (DSB) repair pathway is essential for the maintenance of genomic stability. Here, we show that the Bloom syndrome gene product, BLM, counteracts CtIP/MRE11-dependent long-range deletions (>200 bp) generated by alternative end-joining (A-EJ). BLM represses A-EJ in an epistatic manner with 53BP1 and RIF1 and is required for ionizing-radiation-induced 53BP1 focus assembly. Conversely, in the absence of 53BP1 or RIF1, BLM promotes formation of A-EJ long deletions, consistent with a role for BLM in DSB end resection. These data highlight a dual role for BLM that influences the DSB repair pathway choice: (1) protection against CtIP/MRE11 long-range deletions associated with A-EJ and (2) promotion of DNA resection. These antagonist roles can be regulated, according to cell-cycle stage, by interacting partners such as 53BP1 and TopIII, to avoid unscheduled resection that might jeopardize genome integrity. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved. This article was published in Cell Rep and referenced in Gene Technology

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