alexa A scoring system for the classification of beta-thalassemia Hb E disease severity.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular Biomarkers & Diagnosis

Author(s): Sripichai O, Makarasara W, Munkongdee T, Kumkhaek C, Nuchprayoon I,

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Abstract Beta-thalassemia intermediate patients show a remarkable clinical heterogeneity. We examined the phenotypic diversity of 950 beta-thalassemia/Hb E patients in an attempt to construct a system for classifying disease severity. A novel scoring system based on six independent parameters, hemoglobin level, age at disease presentation, age at receiving first blood transfusion, requirement for transfusion, spleen size, and growth and development, was able to separate patients into three distinctive severity categories: mild, moderate, and severe courses. This system, therefore, can increase the accuracy of studies of genotype-phenotype interactions and facilitate decisions for appropriate patient management. Copyright 2008 Wiley-Liss, Inc. This article was published in Am J Hematol and referenced in Journal of Molecular Biomarkers & Diagnosis

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