Author(s): Bliss TV, Collingridge GL, Bliss TV, Collingridge GL, Bliss TV, Collingridge GL, Bliss TV, Collingridge GL
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Abstract Long-term potentiation of synaptic transmission in the hippocampus is the primary experimental model for investigating the synaptic basis of learning and memory in vertebrates. The best understood form of long-term potentiation is induced by the activation of the N-methyl-D-aspartate receptor complex. This subtype of glutamate receptor endows long-term potentiation with Hebbian characteristics, and allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and postsynaptic mechanisms to generate a persistent increase in synaptic strength.
This article was published in Nature
and referenced in Neurochemistry & Neuropharmacology