alexa A systematic evaluation and validation of subtypes of adolescent alcohol use motives: genetic and environmental contributions.
Psychiatry

Psychiatry

Journal of Child and Adolescent Behavior

Author(s): Mackie CJ, Conrod PJ, Rijsdijk F, Eley TC

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Abstract BACKGROUND: Alcohol use motives are closely associated with specific profiles of alcohol use and reflect a subjectively derived decisional framework based on a motivational style of responding. Adult twin studies typically estimate the heritability of alcohol use motives to be between 7 and 42\%, although relatively little is known about genetic and environmental influences upon alcohol use motives in adolescence. METHODS: Latent class analysis (LCA) models containing 1 through 5 classes were fitted to the data derived from 1,422 adolescent twin and siblings self-reported alcohol use motives. Using twin models, we estimated the genetic, shared, and nonshared environmental influences to the class membership data derived from the LCA. RESULTS: Four drinking motives classes were identified (family-oriented, social, enhancement/social, and coping/social). The coping/social and enhancement/social classes were differentiated from the social class on measures of depression, delinquency, and aggressive behavior. Analyses indicated that nonadditive genetic factors accounted for 76\% of the variance in the coping/social motives class and additive genetic influences accounted for 66\% of the variance in the social motives class. There was a moderate contribution of genetic factors and shared environmental factors influencing class membership of enhancement/social motivated drinkers (28 and 20\% explained variance, respectively). Substantial shared environmental influences were revealed for membership of the family-oriented class (75\%). CONCLUSIONS: Heritable influences may predispose individuals to drink to cope with negative affect, for social reasons, and to a lesser extent for enhancement. Familial environmental influences shape family-oriented motives for drinking in adolescents. Copyright © 2010 by the Research Society on Alcoholism. This article was published in Alcohol Clin Exp Res and referenced in Journal of Child and Adolescent Behavior

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