alexa A systematic review of the application of spatial analysis in pharmacoepidemiologic research.
Pharmaceutical Sciences

Pharmaceutical Sciences

Advances in Pharmacoepidemiology and Drug Safety

Author(s): Dijkstra A, Hak E, Janssen F

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Abstract PURPOSE: Although current reviews of the use of spatial analysis in general epidemiologic research illustrate an important and well-established role in exploring and predicting health, its application has not been reviewed in the subspecialty field of pharmacoepidemiology. METHODS: We systematically reviewed the scientific literature to assess to what extent spatial analysis has been applied in pharmacoepidemiologic research and explored its potential added value. RESULTS: A systematic search in PubMed and Embase/MEDLINE yielded 823 potentially relevant articles; 45 articles met our criteria for review. The studies were reviewed on study objective, applied spatial methods and units of analysis, and author-reported added value of the geographic approach used. Of the 45 included studies, 34 (76\%) reported a geographic research objective. Comparative spatial methods were most often used (n = 25; 56\%). Eleven studies used spatial statistics (32\%); cluster analysis (n = 5) and aggregate data analysis (n = 4) being most common. Mapping was done in 15 studies (33\%). The most common added value reported was to aid the planning of health policies and interventions (n = 24; 53\%). A minority of pharmacoepidemiologic studies used a geographic approach and the applied methods were less advanced compared with the broader field of epidemiology. CONCLUSIONS: Further advancements are needed to incorporate currently available spatial techniques to impact health care planning. Copyright © 2013 Elsevier Inc. All rights reserved. This article was published in Ann Epidemiol and referenced in Advances in Pharmacoepidemiology and Drug Safety

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