alexa A very low dose of green tea polyphenols in drinking water prevents N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Narisawa T, Fukaura Y

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Abstract The effect of tea polyphenols, major constituents of tea, on colon carcinogenesis was investigated. A total of 129 female F344 rats were given an intrarectal instillation of 2 mg of N-methyl-N-nitrosourea 3 times a week for 2 weeks, and received a water solution of green tea extract (GTE) as drinking water throughout the experiment. Autopsies at week 35 revealed significantly lower incidence of colon carcinomas in rats ingesting 0.05\%, 0.01\% or 0.002\% GTE solution than in controls ingesting 0\% GTE solution: 43\%, 40\% and 33\% vs. 67\%. The data suggest that GTE, even at a very low dose (0.002\% solution), has a potent inhibitory effect on colon carcinogenesis.
This article was published in Jpn J Cancer Res and referenced in Journal of Cytology & Histology

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