alexa A viscosity-dependent affinity sensor for continuous monitoring of glucose in biological fluids.


Biochemistry & Analytical Biochemistry

Author(s): Boss C, Meurville E, Sallese JM, Ryser P

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Abstract We present a viscometric affinity biosensor for continuous monitoring of glucose in biological fluids such as blood and plasma. The sensing principle of this chemico-mechanical sensor is based upon the viscosity variation of a sensitive fluid with glucose concentration. Basically, this device includes both an actuating and a sensing piezoelectric diaphragms as well as a flow-resistive microchannel. In order to confine the sensitive fluid and allow glucose diffusion into the sensor, a free-standing alumina nanoporous membrane is also used as size-selective interface. Measurements carried out at nominal temperatures of 25 and 37 °C reveal that this sensor topology exhibits a high resolution in the current range of physiological blood glucose concentrations, i.e. 2-20 mM. In addition, complete reversibility was also demonstrated for at least 3 days. Finally, measurements performed in human blood serum confirm that this sensor fulfils all basic requirements for a use in continuous glucose monitoring of biological fluids. Copyright © 2011 Elsevier B.V. All rights reserved. This article was published in Biosens Bioelectron and referenced in Biochemistry & Analytical Biochemistry

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